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Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State.
McEwen, Abbye E; Cohen, Seth; Bryson-Cahn, Chloe; Liu, Catherine; Pergam, Steven A; Lynch, John; Schippers, Adrienne; Strand, Kathy; Whimbey, Estella; Mani, Nandita S; Zelikoff, Allison J; Makarewicz, Vanessa A; Brown, Elizabeth R; Bakhash, Shah A Mohamed; Baker, Noah R; Castor, Jared; Livingston, Robert J; Huang, Meei-Li; Jerome, Keith R; Greninger, Alexander L; Roychoudhury, Pavitra.
Clin Infect Dis ; 74(6): 1089-1092, 2022 03 23.
Article in English | MEDLINE | ID: covidwho-1703666

ABSTRACT

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1-23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P < .05).


Subject(s)
COVID-19 , SARS-CoV-2 , Base Sequence , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19 Vaccines , Humans , Washington/epidemiology
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